Hippocampal and striatal histomorphology following chronic nicotine administration in female and male rats
نویسندگان
چکیده
منابع مشابه
Hippocampal and striatal histomorphology following chronic nicotine administration in female and male rats
BACKGROUND Nicotine is a subject of continuous research because of its likely ameliorative effects on neurologic and neurodegenerative disorders. PURPOSE This study examined the effects of its chronic subcutaneous administration on hippocampal and striatal microstructure in both female and male rats. METHODS Forty adult female and male Wistar rats were divided into 4 groups. Three experimen...
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An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...
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15 صفحه اولStriatal dopamine levels and changes in mitochondrial function following chronic 3-nitropropionic acid treatment in rats
An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...
متن کاملEffects of Pre-pregnancy Chronic Valproate Administration in Female Rats on Avoidance Memory and Hippocampal Gene Expression of Offspring
Background and purpose: Valproic acid derivatives are histone deacetylases (HDACs) inhibitors. HDACs are important in epigenetic processes. Some epigenetic modifications are inherited. This study aimed at investigating the intergenerational effects of pre-pregnancy chronic valproate consumption on offspring. Materials and methods: In this experimental study, twelve female Wistar rats were rand...
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ژورنال
عنوان ژورنال: Annals of Neurosciences
سال: 2015
ISSN: 0972-7531,0976-3260
DOI: 10.5214/ans.0972.7531.220107